All the actual examples shouldn't differ from the consensus by more than a few substitutions, but counting mismatches in this way can lead to inconsistencies. Thus a consensus sequence is a model for a putative DNA binding site: it is obtained by aligning all known examples of a certain recognition site and defined as the idealized sequence that represents the predominant base at each position. Finally, splice sites (sequences immediately surrounding the exon- intron boundaries) can also be considered as consensus sequences. Transposons act in much the same manner in their identification of target sequences for transposition. In the same way, restriction enzymes usually have palindromic consensus sequences, usually corresponding to the site where they cut the DNA. For example, many transcription factors recognize particular patterns in the promoters of the genes they regulate. Biological significance Ī protein binding site, represented by a consensus sequence, may be a short sequence of nucleotides which is found several times in the genome and is thought to play the same role in its different locations. Such information is important when considering sequence-dependent enzymes such as RNA polymerase. It represents the results of multiple sequence alignments in which related sequences are compared to each other and similar sequence motifs are calculated. In molecular biology and bioinformatics, the consensus sequence (or canonical sequence) is the calculated sequence of most frequent residues, either nucleotide or amino acid, found at each position in a sequence alignment. ( May 2023) ( Learn how and when to remove this template message) Please help improve it to make it understandable to non-experts, without removing the technical details. This article may be too technical for most readers to understand.
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